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Administration
Should be taken with food.
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Special Precautions
Patients with predisposition to thrombosis, including those taking estrogens; vitamin K deficiency, bleeding tendencies (e.g. bleeding peptic ulcers), history of haemorrhagic stroke, inherited bleeding disorder (e.g. haemophilia). Children. Pregnancy and lactation. Monitoring Parameters Monitor serum tocopherol levels regularly; prothrombin time, INR (in patients taking anticoagulants).
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Adverse Reactions
Significant: Vitamin K deficiency; increased risk of thrombosis; necrotising enterocolitis (particularly at large doses in low-birth-weight premature infants).
Eye disorders: Blurred vision.
Gastrointestinal disorders: Nausea; abdominal pain, diarrhoea (at high doses).
General disorders and administration site conditions: Fatigue.
Nervous system disorders: Dizziness, headache.
Psychiatric disorders: Emotional disturbances.
Skin and subcutaneous tissue disorders: Rash.
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Drug Interactions
May increase the risk for bleeding with anticoagulants (e.g. warfarin) or antiplatelets (e.g. aspirin, clopidogrel, ticlopidine). May increase the risk of thrombosis with estrogens. Concomitant use with colestyramine, colestipol or orlistat may interfere with the absorption of vitamin E.
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CIMS Class
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